2023年9月12日 / 最終更新日 : 2023年9月12日 ad_y ニュース

2023年 新着論文 45　発生生物学分野、分子内分泌学研究分野、リエゾンオフィスから論文が発表されました

VDR is an essential regulator of hair follicle regression through the progression of cell death

Life Sci Alliance. 2023 Sep 6;6(11):e202302014. doi: 10.26508/lsa.202302014. Print 2023 Nov.

Authors

Yudai Joko  1   2 , Yoko Yamamoto  3 , Shigeaki Kato  4 , Tatsuya Takemoto  5 , Masahiro Abe  2 , Toshio Matsumoto  1 , Seiji Fukumoto  1 , Shun Sawatsubashi  6   7   8

Affiliations

  • 1 Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • 2 Department of Hematology, Endocrinology and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
  • 3 Department of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
  • 4 Graduate School of Life Science and Technology, Iryo Sosei University, Fukushima, Japan.
  • 5 Laboratory for Embryology, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • 6 Department of Molecular Endocrinology, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan shun-sawa2@umin.ac.jp.
  • 7 Research and Innovation Liaison Office, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • 8 Laboratory of Integrative Nuclear Dynamics, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.

Free PMC article

Abstract

Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as “surviving epithelial strands.” Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage.

© 2023 Joko et al.

Conflict of interest statement

The authors declare that they have no conflict of interest.

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