2024年新着論文 23　糖尿病診療分野から論文が発表されました

Five percent weight loss is a significant 1-year predictor and an optimal 5-year cut-off for reducing the number of obesity-related cardiovascular disease risk components: the Japan Obesity and Metabolic Syndrome Study

Front Endocrinol (Lausanne). 2024 Mar 27:15:1343153. doi: 10.3389/fendo.2024.1343153. eCollection 2024.

Authors

Hajime Yamakage^#¹, Takaaki Jo^#², Masashi Tanaka^1 3, Sayaka Kato^1 4, Koji Hasegawa⁵, Izuru Masuda¹, Munehide Matsuhisa⁶, Kazuhiko Kotani⁷, Mitsuhiko Noda^8 9, Noriko Satoh-Asahara^1 10

Affiliations

¹ Department of Endocrinology, Metabolism, and Hypertension Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, Japan.
² Department of General Internal Medicine, Fushimi Momoyama General Hospital, Kyoto, Japan.
³ Department of Rehabilitation, Health Science University, Minamitsuru-gun, Japan.
⁴ Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
⁵ Division of Translational Research, Clinical Research Institute, NHO Kyoto Medical Center, Kyoto, Japan.
⁶ Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
⁷ Division of Community and Family Medicine, Jichi Medical University, Shimotsuke, Japan.
⁸ Department of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital, International University of Health and Welfare, Ichikawa, Japan.
⁹ Department of Endocrinology and Diabetes, Saitama Medical University, Moroyama, Japan.
¹⁰ Department of Metabolic Syndrome and Nutritional Science, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.

^# Contributed equally.

Abstract

Objective: This study aimed to identify the amount of weight loss needed in patients with obesity to improve metabolic syndrome (MetS), a risk factor for cardiovascular disease (CVD), over a long period of time.

Methods: A total of 576 patients with obesity were enrolled in this study. Effects of continuous physician-supervised weight loss on the cumulative MetS components excluding abdominal circumference (defined as obesity-related CVD risk score) were investigated during a 5-year follow-up period. The extent of weight loss required to reduce the obesity-related CVD risk components was assessed using receiver operating characteristic (ROC) curve analyses.

Results: Of the 576 participants, 266 completed 5-year follow-up, with 39.1% and 24.1% of them achieving ≥5.0% and ≥7.5% weight loss at the 5-year follow-up, respectively. The area under the ROC curve for reducing the obesity-related CVD risk components was 0.719 [0.662-0.777] at 1 year and 0.694 [0.613-0.775] at 5 years. The optimal cut-off value for weight loss was 5.0% (0.66 sensitivity and 0.69 specificity) and the value with 0.80 specificity was 7.5% (0.45 sensitivity) at 5 years. Greater reductions in weight were associated with greater improvements in the obesity-related CVD risk score at all follow-up periods (P-trend <0.001). Obesity-related CVD risk score was significantly improved by 5.0-7.5% and ≥7.5% weight loss at 1 year (P = 0.029 and P < 0.001, respectively) and ≥7.5% weight loss at 5 years (P = 0.034).

Conclusions: A weight loss of ≥5.0% at 1 year and ≥7.5% at 5 years could reduce the number of obesity-related CVD risk components in patients with obesity.

Keywords: 5-year follow-up; cohort study; metabolic syndrome; obesity; weight loss.

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision MT is an Editorial Board Member of this journal but was not involved in the peer-review process nor had access to any information regarding its peer-review.

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