2024年 新着論文 39 糖尿病診療分野から論文が発表されました

Effects of Xanthine Oxidase Inhibition by Febuxostat on Lipid Profiles of Patients with Hyperuricemia: Insights from Randomized PRIZE Study

Nutrients. 2024 Jul 19;16(14):2324. doi: 10.3390/nu16142324.

Affiliations

  • 1 Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, Chiba 260-0856, Japan.
  • 2 Department of Cardiovascular Medicine, Saga University, Saga 849-8501, Japan.
  • 3 Department of Medical Statistics, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.
  • 4 Department of Cardiovascular Medicine, Imamura General Hospital, Kagoshima 890-0064, Japan.
  • 5 Department of Internal Medicine, Chiba Aoba Municipal Hospital, Chiba 260-0852, Japan.
  • 6 Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima 770-8503, Japan.

Abstract

Although patients with hyperuricemia and gout often have dyslipidemia, the effects of febuxostat, a xanthine oxidase inhibitor, on their lipid profiles are unclear. Thus, we performed a sub-analysis of the randomized PRIZE study in which the effects of febuxostat on carotid atherosclerosis were investigated in patients with hyperuricemia. The participants were randomized to the febuxostat or control group. The primary endpoint of this sub-analysis was changes in the patients’ non-high-density lipoprotein cholesterol (HDL-C) levels from baseline to 6-month follow-up. Correlations between the changes in lipid profiles and cardiometabolic parameters were also evaluated. In total, 456 patients were included. From baseline to 6 months, non-HDL-C levels were significantly reduced in the febuxostat group (-5.9 mg/dL, 95% confidence interval [CI]: -9.1 to -2.8 mg/dL, p < 0.001), but not in the control group (-1.3 mg/dL, 95% CI: -4.4 to 1.8, p = 0.348). The reduction in non-HDL-C levels was more pronounced in women and correlated with changes in serum uric acid and estimated glomerular filtration rate levels only in the febuxostat group. In patients with hyperuricemia, febuxostat treatment was associated with reduced non-HDL-C levels from baseline to the 6-month follow-up compared to the control treatment, suggesting that the lipid-lowering effect of febuxostat should be considered when targeting dyslipidemia.

Keywords: cholesterol; dyslipidemia; febuxostat; hyperuricemia.