2025年 新着論文 18 分子生命科学分野から論文が発表されました
Metal-Responsive Up-Regulation of Bifunctional Disulfides for Suppressing Protein Misfolding and Promoting Oxidative Folding
- PMID: 40586367
- DOI: 10.1002/anie.202502187
Abstract
The stress-responsive up-regulation process is a sophisticated biological response to maintain cellular homeostasis. In intracellular anti-oxidant systems, the expression level of oxidoreductases is up-regulated under oxidative stress, mitigating oxidative damage on biomolecules and enhancing protein folding capacity. Herein, inspired by the biological system, we developed a synthetic folding promotor whose reactivity is up-regulated under stress conditions. We conjugated two metal-binding 1,4,7,11-
Keywords: Copper ions; Disulfide bonds; Metal‐induced stress; Oxidative folding; Protein folding.
© 2025 The Author(s). Angewandte Chemie International Edition published by Wiley‐VCH GmbH.