2025年 新着論文 8 糖尿病診療分野から論文が発表されました

Relation between obesity and health disorders as revealed by the J-ORBIT clinical information collection system directly linked to electronic medical records (J-ORBIT 1)

J Diabetes Investig. 2025 Mar 27. doi: 10.1111/jdi.70021. Online ahead of print.

Authors

Seiji Nishikage  1 Yushi Hirota  1 Yasushi Nakagawa  1 Masamichi Ishii  2 Mitsuru Ohsugi  3 Eiichi Maeda  4 Kai Yoshimura  1 Akane Yamamoto  1 Tomofumi Takayoshi  1 Takehiro Kato  5 Daisuke Yabe  5 Munehide Matsuhisa  6 Jun Eguchi  7 Jun Wada  7 Yukihiro Fujita  8 Shinji Kume  8 Hiroshi Maegawa  8 Kana Miyake  9 Nobuhiro Shojima  9 Toshimasa Yamauchi  9 Koutaro Yokote  10 Kohjiro Ueki  11 Kengo Miyo  2 Wataru Ogawa  1

Affiliations

  • 1 Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • 2 Center for Medical Informatics Intelligence, National Center for Global Health and Medicine, Tokyo, Japan.
  • 3 Diabetes and Metabolism Information Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.
  • 4 Division of Medical Informatics, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
  • 5 Department of Diabetes, Endocrinology, and Metabolism and Department of Rheumatology and Clinical Immunology, Gifu University Graduate School of Medicine, Gifu, Japan.
  • 6 Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • 7 Department of Nephrology, Rheumatology, Endocrinology, and Metabolism, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
  • 8 Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
  • 9 Department of Diabetes and Metabolic Disease, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
  • 10 Chiba University, Chiba, Japan.
  • 11 Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan.

Free article

Abstract

Aims/introduction: Obesity triggers various health disorders, but information on these disorders in real-world settings remains limited. To address this knowledge gap, we developed a database directly linked to electronic medical records (EMRs). We here present the baseline data for this database, designated Japan Obesity Research Based on electronIc healTh Records (J-ORBIT).

Materials and methods: Individuals with obesity disease diagnosed according to the criteria of the Japan Society for the Study of Obesity were registered in J-ORBIT from seven medical centers in Japan. We analyzed the relationship between body mass index (BMI), clinical characteristics, and the prevalence of obesity-related health disorders in this cohort.

Results: Data were obtained from 1,169 individuals, with a mean (±SD) age of 56.9 ± 15.3 years and a BMI of 31.4 ± 6.1 kg/m2. The prevalence of health disorders varied substantially across BMI categories, with a higher BMI being associated with an increased prevalence of hyperuricemia or gout, obstructive sleep apnea syndrome or obesity hypoventilation syndrome, musculoskeletal disorders, and obesity-related kidney disease, as well as with a higher frequency of both a family history of obesity and of a history of childhood obesity. Among individuals with a BMI of ≥25 kg/m2, the prevalence of hypertension and dyslipidemia did not increase with BMI, whereas that of glucose intolerance decreased with increasing BMI.

Conclusions: The J-ORBIT system, which collects clinical data in real time directly from EMRs, has the potential to provide insight into obesity and its associated health conditions, thereby contributing to improved care of affected individuals.

Keywords: Body mass index; Electronic medical records; Obesity.

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