2022年 新着論文 29 糖尿病診療分野から論文が発表されました

Chronic Intake of a Meal Including Alaska Pollack Protein Increases Skeletal Muscle Mass and Strength in Healthy Older Women: a Double-Blind Randomized Controlled Trial

J Nutr. 2022 Sep 22;nxac219. doi: 10.1093/jn/nxac219. Online ahead of print.

Authors

Affiliations

  • 1 Diabetes Therapeutics and Research Center, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, Japan.
  • 2 Hyogo Himeji Welfare Community, Nonprofit Organization, Hyogo, Japan.
  • 3 Food Function R&D Center, Nippon Suisan Kaisha, Ltd., Tokyo, Japan.

Abstract

Background: In animal studies, a meal containing Alaska pollack protein (APP) induces fast-twitch muscle hypertrophy. To our knowledge, no interventional studies have examined the benefits of APP intake on muscle mass and muscle weakness and the prevention of sarcopenia in older individuals.

Objectives: We evaluated the effects of APP intake on skeletal muscle mass, muscle strength, and physical performance among healthy community-dwelling older Japanese women.

Methods: In this double-blind randomized controlled trial, healthy women ≥ 65 y were allocated to an APP or whey protein control (CON) group. Participants ingested test protein meals (5.0-5.1 g of protein per serving) daily for 24 wk. Between-group differences in the change of skeletal muscle mass index (SMI) as the primary outcome and muscle strength as a secondary outcome were tested using multi-frequency bioelectrical impedance analysis and a hand-held dynamometer, respectively, at baseline, and 4, 12, and 24 wk. The mean changes in the measured primary and secondary outcome variables from baseline to 4, 12, and 24 wk were compared using unpaired t-tests.

Results: There were no between-group differences in nutritional status, food intake, or total energy and protein intakes at baseline, 12 wk, or 24 wk. The change in SMI was 0.12 kg/m2 (95% confidence interval [CI]: 0.01-0.23 kg/m2) and 0.11 kg/m2 (95%CI: 0.03-0.19 kg/m2) greater in the APP group compared with the CON group at 12 wk and 24 wk (P ≤ 0.03) and knee extension strength was 0.07 Nm/kgBW (95%CI: 0.02-0.12 Nm/kgBW) and 0.05 Nm/kgBW (95%CI: 0.00-0.09 Nm/kgBW) higher at these times (P ≤ 0.015), respectively. The groups did not differ at 4 wk.

Conclusions: Daily intake of a meal containing APP compared with whey protein increases skeletal muscle mass and lower-extremity muscle strength in healthy older women, suggesting that an APP-containing meal may be useful in the prevention of sarcopenia in this group.

Keywords: alaska pollack protein; muscle strength; older adults; randomized controlled trial; skeletal muscle mass.

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