2022年 新着論文 30 分子内分泌学研究分野から論文が発表されました

Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review

J Bone Miner Res. 2022 Sep 25. doi: 10.1002/jbmr.4714. Online ahead of print.

Authors

Affiliations

  • 1 Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
  • 2 University of California, San Francisco, Zuckerberg San Francisco General Hospital, San Francisco, CA, USA.
  • 3 Vagelos College of Physicians and Surgeons of Columbia University, New York, NY, USA.
  • 4 Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 770-8503, Japan.
  • 5 Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, 110029, India.
  • 6 Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Département de Physiologie, F-75006, Paris, France.
  • 7 University of Pennsylvania, Director, Center for Bone Health, Children’s Hospital of Philadelphia, Philadelphia, PA.
  • 8 Division of General Surgery, Department of Surgery, University Health Network, University of Toronto, Toronto, Canada.
  • 9 University of Texas MD Anderson Cancer Center, Department of Surgical Oncology, Section of Surgical Endocrinology, Houston, USA.
  • 10 Universitat Autònoma de Barcelona, Endocrine Surgery, Hospital del Mar, Barcelona, Spain.
  • 11 University of California, San Francisco, Endocrine Research Unit, San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.

Abstract

The approach utilized a systematic review of the medical literature executed with specifically designed criteria that focused on the etiologies and pathogenesis of hypoparathyroidism. Enhanced attention by endocrine surgeons to new knowledge about parathyroid gland viability are reviewed along with the role of intraoperative parathyroid hormone (ioPTH) monitoring during and after neck surgery. Nonsurgical etiologies account for a significant proportion of cases of hypoparathyroidism (~25%), and among them, genetic etiologies are key. Given the pervasive nature of PTH deficiency across multiple organ systems, a detailed review of the skeletal, renal, neuromuscular and ocular complications is provided. The burden of illness on affected patients and their caregivers contributes to reduced quality of life and social costs for this chronic endocrinopathy. This article is protected by copyright. All rights reserved.

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