2022年新着論文 38　細胞情報学分野から論文が発表されました

A Wolbachia factor for male killing in lepidopteran insects.

Nat Commun. 2022 Nov 14;13(1):6764. doi: 10.1038/s41467-022-34488-y.

Authors

Susumu Katsuma^#¹, Kanako Hirota^#², Noriko Matsuda-Imai^#², Takahiro Fukui², Tomohiro Muro², Kohei Nishino³, Hidetaka Kosako³, Keisuke Shoji⁴, Hideki Takanashi², Takeshi Fujii⁵, Shin-Ichi Arimura², Takashi Kiuchi²

Affiliations

¹Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan. skatsuma@g.ecc.u-tokyo.ac.jp.
²Department of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan.
³Division of Cell Signaling, Fujii Memorial Institute of Medical Sciences, Institute of Advanced Medical Sciences, Tokushima University, Tokushima, 770-8503, Japan.
⁴Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-0032, Japan.
⁵Faculty of Agriculture, Setsunan University, 45-1 Nagaotoge-cho, Hirakata, Osaka, 573-0101, Japan.

PMID:36376299
PMCID: PMC9663696
DOI: 10.1038/s41467-022-34488-y

Abstract

Bacterial symbionts, such as Wolbachia species, can manipulate the sexual development and reproduction of their insect hosts. For example, Wolbachia infection induces male-specific death in the Asian corn borer Ostrinia furnacalis by targeting the host factor Masculinizer (Masc), an essential protein for masculinization and dosage compensation in lepidopteran insects. Here we identify a Wolbachia protein, designated Oscar, which interacts with Masc via its ankyrin repeats. Embryonic expression of Oscar inhibits Masc-induced masculinization and leads to male killing in two lepidopteran insects, O. furnacalis and the silkworm Bombyx mori. Our study identifies a mechanism by which Wolbachia induce male killing of host progeny.

カテゴリー: ニュース